Pinealon
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
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What is Pinealon?
Pinealon is a very short, lab-made tripeptide (three amino acids) developed as part of a Russian bioregulator research program, studied for how it may interact with gene expression in neurons. Animal and cell-culture research reports effects on markers of neuroprotection and cognitive-aging pathways, though independent research outside that original program is limited. It's sold here strictly as a research chemical for laboratory study, not for use in people or animals.
Key terms:
Pinealon is a synthetic tripeptide.
Pinealon (Glu-Asp-Arg/EDR) is a lab-made peptide of three amino acids, a bioregulator developed in Russia. Research describes unusual DNA-interaction capabilities linked to neuroprotection (nerve protection) and cognitive enhancement. Studies suggest benefits for traumatic brain injury recovery, age-related cognitive decline, and cellular aging processes, through direct changes in gene expression.
Key research areas
- Highest bioavailability via subcutaneous injection
- Direct systemic delivery
- Established clinical protocols with proven efficacy
- Neuroprotection through DNA interaction
- Cognitive enhancement and longevity benefits
Researched dosing
This table shows how researchers have structured study dosing schedules for Pinealon, including the multi-week research courses used in the original clinical program — published research methodology, not personal usage instructions.
| Phase | Dose | Frequency | Route |
|---|---|---|---|
| Neuroprotection models | 5mg daily | Once daily | Subcutaneous |
| Cognitive-performance studies | 100-300μg | Daily or every other day | Subcutaneous |
| Longevity protocols | 5mg daily | 20 days, 2-3x yearly | Subcutaneous |
Commonly cycled 3 weeks on, 8+ weeks off.
How it works
At the cell level, Pinealon research proposes that this short peptide can enter the cell nucleus and interact directly with DNA — an unusual mechanism compared with peptides that only act on surface receptors.
Subcutaneous injection provides optimal bioavailability and systemic distribution for neuroprotection and DNA interaction.
Molecular data
These figures — molecular weight, three-amino-acid sequence, chain length — are the chemistry fingerprint researchers use to confirm a Pinealon sample's identity; at just three amino acids, it's one of the shortest peptides studied in this encyclopedia.
- Weight
- 418.4 Da
- Length
- 3 amino acids
- Type
- Tripeptide
Glu-Asp-Arg (EDR)
Pharmacokinetics
This chart shows how quickly Pinealon clears in research studies — the timescale is minutes, which is part of why laboratory protocols dose it daily rather than relying on a single long-acting dose.
- Peak
- 0.05 hr
- Half-life
- 0.5 hrs
- Cleared
- ~2.5 hrs
Based on pharmacokinetic studies
Research applications
This section lists the body systems and research areas scientists have studied for Pinealon — largely animal and cell-culture neuroprotection research from the program that developed it — a summary of what's been investigated in the literature, not medical claims about people.
Neuroprotection
Clinical protocol of 5mg daily subcutaneous injection showed significant cognitive improvements in 72-patient study. Subcutaneous administration allows systemic circulation to brain tissue for neuroprotective effects. Injectable route provides highest systemic exposure for maximal therapeutic effects.
Cognitive
Dose-response study identifying 100 ng/kg as optimal for spatial learning improvement. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.
Longevity
Mechanistic study demonstrating antioxidant effects at lower concentrations with cell cycle modulation at higher doses. Concentration-dependent neuroprotective effects confirmed.
Dosage reference
- Doses used in research
- 5 mg
- Frequency in studies
- Once daily
- Handling
- Reconstituted solution — research use only; not for administration
- Timeline reported in studies
- 1-2 weeks initial effects, 3-4 weeks full benefits
- Storage
- Refrigerate at 2-8°C, use within 30 days
- Cycle length
- 20 days
- Break between cycles
- 2-3 month rest periods
Interactions
This list shows which other bioregulator-class peptides researchers study alongside Pinealon, most of them from the same research program.
Reconstitution & storage
This is the standard laboratory method for turning freeze-dried Pinealon powder into a liquid research solution — the same basic water-based mixing process used for most peptide research.
- Remove lyophilized powder and bacteriostatic water from refrigeration
- Clean vial tops with alcohol swabs and allow to dry
- Draw appropriate volume of bacteriostatic water into syringe
- Inject water slowly down the side of the peptide vial to avoid foam
- Gently swirl (do not shake) until powder dissolves completely
- Store the reconstituted solution refrigerated (2–8°C), labeled with the date and concentration, for laboratory research use only.
Lyophilized: 2-8°C, use within Per manufacturer expiration date
Reconstituted: 2-6°C, use within 30 days
Open the Pinealon reconstitution calculatorQuality indicators
These are the visual checks researchers use to confirm a Pinealon sample is pure and correctly identified before it goes into a study.
White Crystalline Powder - Lyophilized powder should appear white and crystalline, indicating proper freeze-drying
Clear Solution - Reconstituted solution should be crystal clear with no particles
Discolored Powder - Yellow or brown coloration indicates degradation
What to expect
This timeline summarizes what the research program's reported observations describe at each stage of a study — research context for comparing studies, not a personal-results promise.
Improved mental clarity and focus
Enhanced cognitive processing and memory
Peak neuroprotective and longevity benefits
Safety notes
This section covers handling cautions and regulatory notes for Pinealon in a laboratory setting — it has no FDA approval and limited research outside the program that developed it, research-use-only scope, not medical safety advice for people.
- Use sterile injection technique
- Rotate injection sites to prevent irritation
- Store reconstituted peptide in refrigerator
- Medical supervision recommended
- Not FDA-approved - developed in Russia as a bioregulatory peptide
Regulatory status
- Not approved by the FDA for any indication.
- Supplied and described for laboratory research use only — not for human or veterinary use.
Community data
Community Insights
Based on data the community reported. Not clinical proof.
References
Prevention of dendritic spine loss in established Alzheimer's model. Significant neuroprotection through MAPK/ERK pathway modulation and reduced neuroinflammation.
Dose-response study identifying 100 ng/kg as optimal for spatial learning improvement. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.
Mechanistic study demonstrating antioxidant effects at lower concentrations with cell cycle modulation at higher doses. Concentration-dependent neuroprotective effects confirmed.