Fat Loss
Retatrutide 10mg
One of the most closely watched compounds in metabolic research. Studied for how it acts on the body's fat-storage, blood-sugar, and energy-use pathways. Research-grade Retatrutide (LY3437943) is a synthetic 39-amino-acid triple GLP-1/GIP/glucagon receptor agonist peptide.
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Orders by 1:30 PM MT ship the same dayShips from Canada, every day
- Free shipping over $140. Most Canadian stores start free shipping at $200.
- Discreet, unmarked packaging.
- Third-party tested by Janoshik
- 99.76% purity, batch LXB-RETA-20260701-01
Reconstitution calculator for Retatrutide 10mg →
- Tested by Janoshik, every batchIndependent HPLC and mass spec. The lab is named on the report.
- The report is public before you orderPublished under the lot number printed on the vial, so you can match them on arrival.
- Ships from Canada within 24 hoursTracked and discreet. Free shipping over $140.
Certificate of Analysis
Batch LXB-RETA-20260701-01
- Purity (HPLC)
99.76% - Reported mass
- 9.76mg
- Test date
- 2026-07-07
- Format
- Lyophilized powder
- Storage
- −20°C (long-term)
- Shipping
- Canadian domestic
- Testing
- HPLC purity + content
How a triple agonist works, in plain words
- Retatrutide docks on three receptors. GLP-1 is the docking point for moving food along the gut and answering blood sugar with insulin.
- GIP is the second docking point, the one for the signals that handle fat and energy.
- Glucagon is the third docking point, the one for the signal that tells the liver to use fat for fuel.
- Semaglutide reaches only GLP-1, so it touches the gut and insulin signals alone. Tirzepatide adds GIP. Neither reaches glucagon.
- The trial results are for the whole molecule. The trials did not separate the three switches.
These are findings investigators reported in trial participants, people enrolled in registered studies and given the compound as a medicine under test. They are not a result for this vial, and not a result for any reader. Everything Lux BioPure sells is supplied for laboratory research use only.
- [1]Triple-Hormone-Receptor Agonist Retatrutide for Obesity, a Phase 2 TrialNew England Journal of Medicine, 2023
- [2]Retatrutide in people with type 2 diabetes and inadequate control on diet and exercise (TRANSCEND-T2D-1), a phase 3 trialThe Lancet, 2026
How it works, step by step
Step 1 of 3GLP-1 receptor
Step 1 · Target
GLP-1 receptor
- A gut hormone released after eating.
- Retatrutide sits in its docking point and switches it on.
- Studied in animals for how the gut moves food along and how insulin answers a rise in blood sugar.
The one switch a single agonist works through
- A compound that reaches GLP-1 alone has this switch and no other.
- Animal work follows the gut and the insulin answer from here.
Measured48-week trial, 338 adults: weight fell 24.2% on the highest dose, 2.1% on placebo, which carries no active drug.New England Journal of Medicine, 2023
Step 2 of 3GIP receptor
Step 2 · Target
GIP receptor
- A second gut hormone, also released after a meal.
- Retatrutide switches on its docking point as well.
- Studied in animals for how fat and energy are handled.
The second switch, what makes a dual agonist
- Reaching GLP-1 and GIP together is what a dual agonist does.
- Animal models follow fat and energy from here.
Measured40-week trial in adults with type 2 diabetes: A1C, the blood test for average blood sugar, fell 1.7 to 2.0 points.The Lancet, 2026
Step 3 of 3Glucagon receptor
Step 3 · Target
Glucagon receptor
- The hormone that raises blood sugar, the opposite number to insulin.
- Retatrutide switches on its docking point too, the third of three.
- Studied for how the liver uses fat for fuel, and for how much energy is used in a day.
The pathway one- and two-receptor compounds leave alone
- Retatrutide is the only one of the three that reaches it.
- This third switch is why the design is called a triple agonist.
MeasuredSame 40-week trial: weight fell by up to 16.8% at the highest dose. Retatrutide is not approved anywhere.The Lancet, 2026
In contextSingle, dual, triple
Single, dual, triple
Which docking points each molecule reaches. Trial results are for whole molecules. How much each switch adds on its own was not separated.
- SingleSemaglutideGLP-1, reached GIP, not reached Glucagon, not reached
- DualTirzepatideGLP-1, reached GIP, reached Glucagon, not reached
- TripleRetatrutide, this pageGLP-1, reached GIP, reached Glucagon, reached
What is Retatrutide 10mg?
That triple-receptor action is what sets Retatrutide apart from dual-agonist compounds, which target only two.
Preclinical research has explored its role in fat-tissue loss, insulin sensitivity, and how much energy the body burns. That triple-agonist profile makes it a compound of interest in metabolic syndrome research.
Comes as lyophilized powder in a 10 mg vial, singly or as a 10-vial pack. Mix with bacteriostatic water before use in a research protocol.
What is the molecule?
- Formula
- C₂₂₁H₃₄₂N₄₆O₆₈
- Mol. Weight
- 4,731.3 Da
- Sequence length
- 39 amino acids
- Half-life (est.)
- ≈ 6 days (sc)
- CAS
- 2381089-83-2
- Research code
- LY3437943
- For laboratory research use only.
- Not for human or veterinary use.
- Not intended for diagnosis, treatment, cure, or prevention of any disease.
- Use only in a controlled lab setting, and only by trained staff.
Research Profile
preclinical research consensus for informational comparison only
What arrives, and what to do with it
The vial ships lyophilized, a sealed powder, not a ready-to-use liquid. It needs bacteriostatic water and a clean workspace before it is usable in a protocol.
What's in the box
One sealed 10 mg vial of lyophilized powder, with its lot number printed on the label. The 10-pack is ten of that same vial. Bacteriostatic water is sold separately, so it goes in the order too if there is none on the bench.
Store cold, warm before opening
The label on the vial says it plainly: store in a cool, dark place. A 2-8°C fridge shelf covers that for up to three months, and the spec sheet figure of -20°C suits a long hold. Bring the vial to room temperature for 15 to 20 minutes before opening. That is a handling step, not a storage change. Once reconstituted, refrigerate at 2-8°C and use within 28 days.
How to tell it went right
A properly reconstituted vial dissolves into a clear, colorless solution, with no cloudiness and no particles. If it does not, or if the lot on the vial does not match the report on our lab reports page, stop and contact us before it goes into a protocol.
Where to read more
Questions about Retatrutide 10mg
What is retatrutide studied for?
Metabolic research studies how it acts on three hormone receptors at once. In a 48-week phase 2 trial of 338 adults published in the New England Journal of Medicine in 2023, average weight fell 24.2% in the highest-dose group, against 2.1% in the placebo group, a dummy treatment with no active drug in it. That is what investigators reported in trial participants, and not a result for this vial.
[1]Triple-Hormone-Receptor Agonist Retatrutide for Obesity, a Phase 2 TrialNew England Journal of Medicine, 2023
How is retatrutide different from tirzepatide and semaglutide?
By how many docking points it reaches. Retatrutide reaches three, GLP-1, GIP and glucagon; tirzepatide reaches GLP-1 and GIP; semaglutide reaches GLP-1 alone. The published figures are for each whole molecule, because no trial separated the switches.
Is retatrutide legal to buy in Canada for research?
Research peptides sold only for in vitro laboratory use sit in a legally distinct category from approved drugs, and that is the category this vial is sold in. Health Canada classifies a substance by marketing intent under the Food and Drugs Act, not by molecular structure, and Canada runs no licensing registry for research chemicals. Retatrutide holds no Drug Identification Number.
How is each batch tested?
An independent lab, Janoshik, runs HPLC and mass spec on every batch before it goes on sale. The report is published under the lot number printed on the vial label, so the two can be matched on arrival. The HPLC purity recorded for this product is 99.76%.
What arrives in the box, and how is it stored?
One sealed 10 mg vial of lyophilized powder, with its lot number printed on the label. The label says to store it in a cool, dark place: a 2-8°C fridge shelf covers that for up to three months, and the spec sheet figure of -20°C suits a long hold. Once reconstituted it is refrigerated at 2-8°C and used within 28 days.
Is retatrutide for human use?
No. Everything Lux BioPure sells is supplied for laboratory research use only, not for human or veterinary use, and not to diagnose, treat, cure or prevent any disease. Retatrutide is not approved anywhere: every figure on this page comes from a compound still being tested.
Pairs With
Frequently asked questions
Are Lux BioPure products for human consumption?
No. All products are sold strictly for lab and research use only. They are not meant to diagnose, treat, cure, or prevent any disease.
How are your peptides tested for purity?
An independent third-party lab checks every batch before we put it on sale. Results show 99%+ purity.
How fast is shipping in Canada?
Orders usually ship within 24 hours. Shipping is a flat $20 anywhere in Canada, and it is free on orders above $140 after coupons. No tax is added: the price plus shipping is what you pay.
Do I need to be a certain age to purchase?
Yes. You must be 19 years of age or older to purchase from Lux BioPure.
For research purposes only. Not for human consumption. All products are sold strictly as research chemicals for in vitro laboratory use.