CJC-1295 with DAC
Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release
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What is CJC-1295 with DAC?
CJC-1295 with DAC is a lab-made version of growth hormone-releasing hormone (GHRH), chemically modified with a molecule called DAC so it clears the body far more slowly than the natural hormone. Researchers study it for how continuous, extended GHRH-receptor signaling compares with the body's normal pulsed release pattern, including effects on the GH/IGF-1 axis. It's sold here strictly as a laboratory research chemical, not for use in people or animals.
Key terms:
CJC-1295 with DAC is a synthetic ghrh analog with dac.
CJC-1295 with DAC is a lab-made version of growth hormone releasing hormone (GHRH), the natural signal that tells the pituitary gland to release growth hormone. DAC stands for Drug Affinity Complex, an added group that makes the peptide last much longer — a half-life of 6 to 8 days. That gives a steady rise in growth hormone instead of the natural bursts. The long-acting form is convenient, but it looks very different from the body's own release pattern.
Key research areas
- Convenient weekly dosing
- Sustained GH/IGF-1 elevation
- Significant body composition changes
Researched dosing
This table reflects how researchers have structured study dosing schedules for CJC-1295 with DAC — published research methodology, not personal dosing guidance.
| Phase | Dose | Frequency | Route |
|---|---|---|---|
| Lower-dose longevity studies | 1mg | Once weekly | Subcutaneous |
| Standard study protocol | 2mg | Once weekly | Subcutaneous |
| Split-dosing studies | 1mg | Twice weekly (Mon/Thu) | Subcutaneous |
| Loading protocol | 2mg first week, then 1mg | Weekly | Subcutaneous |
Commonly cycled 12 weeks on, 4+ weeks off.
How it works
At the cell level, research on CJC-1295 with DAC looks at how the DAC modification anchors the molecule to albumin in the blood, keeping GHRH-receptor stimulation switched on for days instead of minutes.
DAC technology binds to albumin, extending half-life to 6-8 days and providing continuous GHRH receptor stimulation.
Molecular data
These figures — molecular weight, chain length, sequence — are the chemistry fingerprint researchers use to confirm a sample is genuinely CJC-1295 with the DAC modification attached, not the shorter-acting non-DAC version.
- Weight
- 3647.28 Da
- Length
- 30 amino acids
- Type
- GHRH analog with DAC
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys
Pharmacokinetics
This chart shows how a research dose clears over roughly a week rather than the 30 minutes typical of non-DAC GHRH analogs — the long, flat curve is the DAC modification's defining feature in the literature.
- Peak
- 2 hr
- Half-life
- 168 hrs
- Cleared
- ~840 hrs
Teichman et al. 2006
Research applications
This section summarizes the body systems and research questions scientists have studied for CJC-1295 with DAC — a summary of what's been investigated in animal and laboratory research, not medical claims about people.
Growth Hormone
Provides continuous growth hormone release for 6-8 days per injection. Significantly elevates IGF-1 levels for extended periods. Weekly dosing schedule ideal for those seeking simple administration.
Body Composition
Visible body composition changes and increased vascularity observed during research protocols.
Longevity
Supports longevity benefits through sustained GH and IGF-1 elevation over extended periods.
Dosage reference
- Doses used in research
- 1–2 mg (0.5–1 mL at a 2 mg/mL mixing ratio)
- Frequency in studies
- Once weekly - same day each week
- Handling
- Reconstituted solution — research use only; not for administration
- Timeline reported in studies
- IGF-1 elevation within 24-48 hours, peak benefits weeks 2-6, body composition changes weeks 4-8
- Storage
- Refrigerate immediately, more stable than non-DAC - use within 60 days
- Cycle length
- 8-12 weeks maximum
- Break between cycles
- 4-6 weeks mandatory to prevent desensitization
Interactions
This list shows which other growth-hormone-axis peptides researchers study alongside CJC-1295 with DAC, and flags combinations that raise extra caution in a research setting because of overlapping mechanisms.
Reconstitution & storage
This describes the standard laboratory process for turning freeze-dried CJC-1295 with DAC powder into a liquid research solution — DAC-modified peptides are known in the literature to foam more than most, which this section explains how to handle.
- Clean both vial tops with alcohol and let dry completely.
- For 2mg vial: Add 1mL bacteriostatic water (creates 2mg/mL concentration).
- For 5mg vial: Add 2.5mL bacteriostatic water (creates 2mg/mL concentration).
- Inject water very slowly to prevent foaming - DAC peptides foam easily.
- Let sit for 5 minutes before gently rolling to mix.
- Solution may appear slightly cloudy initially but should clear.
- Label with date and concentration immediately.
Lyophilized: Room temperature or refrigerated, use within Up to 24 months if stored properly
Reconstituted: 2-6°C, use within 60 days
Open the CJC-1295 DAC reconstitution calculatorQuality indicators
These are the visual and documentation checks researchers use to confirm a CJC-1295 with DAC sample is genuine and hasn't degraded — since the DAC version costs more to manufacture, unusually low pricing is itself a quality flag.
High purity requirement - DAC peptides require >98% purity - impurities cause more side effects
Proper DAC labeling - Legitimate products clearly state "with DAC" to distinguish from regular CJC-1295
More expensive than non-DAC - DAC version costs 2-3x more due to complex manufacturing
Foaming during mixing - Normal for DAC peptides to foam - wait for foam to settle
Extremely cheap pricing - If priced similar to non-DAC version, likely mislabeled or fake
Clear solution immediately - Should be slightly cloudy initially - immediate clarity may indicate non-DAC
What to expect
This timeline summarizes what research literature and reported laboratory observations describe at each study stage — context for comparing studies, not a personal-results promise.
Possible water retention, improved sleep, increased appetite.
Noticeable recovery improvements, some report joint discomfort.
Visible body composition changes, increased vascularity.
Continued improvements but watch for desensitization signs.
Maintain most gains; IGF-1 returns to baseline in 2-3 weeks.
Safety notes
This section covers handling cautions and regulatory notes for CJC-1295 with DAC in a laboratory setting — research-use-only scope and monitoring flags drawn from the literature, not medical safety advice for people.
- Not suitable for those with diabetes or cancer history
- May worsen sleep apnea in predisposed individuals
- Monitor for signs of excessive GH: jaw growth, hand/feet enlargement
Regulatory status
- Not approved by the FDA for any indication.
- Supplied and described for laboratory research use only — not for human or veterinary use.
Community data
Community Insights
Based on data the community reported. Not clinical proof.
Frequently asked questions
What is CJC-1295 with DAC?
CJC-1295 with DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) modified with a Drug Affinity Complex (DAC). In the research literature the DAC modification is described as extending the molecule's half-life to roughly 6–8 days, giving continuous rather than pulsatile GHRH-receptor signaling. Lux BioPure supplies it strictly as a research chemical for laboratory study, not for use in people or animals.
What class of compound is CJC-1295 with DAC?
CJC-1295 with DAC is classified as a synthetic GHRH analog carrying a DAC modification. It is a 30-amino-acid peptide of about 3,647 daltons. The literature notes the DAC group anchors the molecule to albumin in the blood, which distinguishes it from the shorter-acting non-DAC version. Researchers use these molecular figures to confirm a sample's identity. It is sold for research use only.
How is CJC-1295 with DAC reconstituted for research use?
In the laboratory, lyophilized CJC-1295 with DAC is reconstituted with bacteriostatic water added very slowly, because DAC-modified peptides are known to foam easily. The vial is left to sit for a few minutes, then gently rolled to mix; the solution may look slightly cloudy at first before clearing. It is labeled with its date and concentration. This is standard peptide-handling methodology.
How should reconstituted CJC-1295 with DAC be stored in the lab?
Lyophilized CJC-1295 with DAC can be kept at room temperature or refrigerated and stays stable for up to about 24 months when stored properly. Once reconstituted, the research solution is refrigerated at roughly 2–6°C and used within about 60 days. Because the DAC version is costlier to manufacture, unusually cheap pricing is itself treated as a quality red flag.
How do researchers verify a CJC-1295 with DAC sample?
Researchers check that a sample is clearly labeled "with DAC" to distinguish it from regular CJC-1295, and look for documentation of greater than 98% purity, since impurities are associated with more side effects in the literature. A slight initial cloudiness that clears is expected, whereas immediate clarity or suspiciously low pricing may indicate a mislabeled or non-DAC product.
References
DAC version showed 120-hour half-life versus 30-minute half-life of non-DAC, but non-DAC preserved more physiological GH patterns.
View StudyChronic administration led to sustained IGF-1 elevation but some evidence of reduced GH pulse amplitude, suggesting partial desensitization.
Established optimal dosing at 1-2mg weekly, showing dose-dependent IGF-1 increases but also higher side effect incidence at doses above 2mg.