5-Amino-1MQ
NNMT Inhibitor | Longevity & Metabolic Enhancement
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What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule, not a peptide, that researchers study for its effect on an enzyme called NNMT, which is involved in how cells manage a molecule called NAD+ used for energy production. It's taken orally in research protocols and is being studied for possible roles in cellular metabolism and longevity research. Human clinical trials have not been published; the available evidence comes from animal studies, and this compound is sold here strictly for laboratory research, not human or animal use.
Key terms:
5-Amino-1MQ is a small molecule.
5-Amino-1MQ is a small lab-made molecule. It blocks an enzyme called NNMT (nicotinamide N-methyltransferase). Blocking NNMT raises cell levels of NAD+ (a molecule cells use to make energy) and supports mitochondrial function. It was first developed for metabolic research. Researchers now also study it for longevity roles and for how it changes energy use in cells.
Key research areas
- Enhanced NAD+ levels
- Improved mitochondrial function
- Longevity benefits
- Better energy metabolism
- Enhanced cellular repair
- Improved insulin sensitivity
- Convenient daily dosing
Researched dosing
This table reflects the oral dose ranges researchers have used in study designs with 5-Amino-1MQ, presented as research methodology, not personal usage guidance.
| Phase | Dose | Frequency | Route |
|---|---|---|---|
| Lower-dose studies | 25mg | 1x daily | Oral (with food) |
| Starting dose | 50mg | 1x daily | Oral (with food) |
| Maintenance | 75mg | 1x daily | Oral (with food) |
| Highest dose studied | 100mg | 1x daily | Oral (with food) |
| Split-dosing studies | 50mg | 2x daily | Oral (with meals) |
Commonly cycled 12 weeks on, 2+ weeks off.
How it works
At the cell level, 5-Amino-1MQ research looks at how the molecule blocks the NNMT enzyme, which is thought to help preserve NAD+, a molecule cells use for energy production — the terms below just name that pathway.
Orally administered 5-Amino-1MQ inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining higher cellular NAD+ levels throughout the body, supporting mitochondrial function and metabolic processes
Pharmacokinetics
This chart shows how a research dose of 5-Amino-1MQ is absorbed and cleared over time in animal studies — read it like a timer: the peak is when levels are highest, then the curve trails off as the compound clears.
- Peak
- 0.8 hr
- Half-life
- 8 hrs
- Cleared
- ~40.8 hrs
Rat Pharmacokinetics Study (2021) - PubMed 34304009. Demonstrated 38.4% oral bioavailability.
Research applications
This section lists the research areas — metabolic and longevity research chief among them — that scientists have studied for 5-Amino-1MQ, based entirely on animal studies so far, not human clinical trials.
Longevity
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging. Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging. Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Metabolism
Supports metabolic processes through improved mitochondrial function and NAD+ availability, contributing to better energy metabolism and insulin sensitivity.
Weight Reduction
May support fat reduction and body composition changes through enhanced metabolic function and improved mitochondrial efficiency.
Dosage reference
- Doses used in research
- 50–75 mg
- Frequency in studies
- Once daily with food
- Handling
- Reconstituted solution — research use only; not for administration
- Timeline reported in studies
- Energy: 1-2 weeks, Metabolic: 4-8 weeks, Longevity: 8-12 weeks
- Storage
- Cool, dry place at room temperature
- Cycle length
- 8-12 weeks
- Break between cycles
- 2-4 weeks off between cycles
Interactions
This list shows which other metabolic-research compounds are studied alongside 5-Amino-1MQ, and why.
Reconstitution & storage
5-Amino-1MQ is typically studied as a pre-made capsule or precisely measured powder rather than an injectable, so this section covers handling notes for oral research use.
- Use pre-made capsules for convenience and accuracy (recommended)
- If using powder: measure precise dose with milligram scale
- Maintain consistent daily timing for optimal results
- Consider cycling: 8-12 weeks on, 2-4 weeks off
- Store the reconstituted solution refrigerated (2–8°C), labeled with the date and concentration, for laboratory research use only.
Lyophilized: Room temperature, cool and dry place, use within Per manufacturer expiration date
Reconstituted: 2-6°C, use within Not applicable - oral formulation
Quality indicators
These are the documentation and sourcing checks researchers use to confirm a 5-Amino-1MQ sample is properly manufactured and tested before it goes into a study.
White to off-white capsules - High-quality capsules should be uniform in color and size with clear labeling and batch information
Third-party testing certificates - Reputable suppliers provide COA with purity analysis (should be >98% pure) and heavy metal testing
Proper pharmaceutical packaging - Sealed bottles with moisture protection, clear expiration dates, and professional labeling
Moisture damage or clumping - Capsules should not be sticky, discolored, or show signs of moisture exposure or heat damage
Unusual odor or appearance - Should be relatively odorless; strong chemical odors may indicate contamination or degradation
What to expect
This timeline summarizes what the available animal-model research reports at each stage — research context for comparing studies, not a personal-results promise, since no human trials have been published.
Gradual increase in energy levels and mental clarity
Enhanced exercise performance and recovery
Improved metabolic markers and body composition
Sustained longevity benefits and cellular health
Safety notes
This section covers handling and regulatory notes for 5-Amino-1MQ — research-use-only scope, since no human clinical safety data currently exists.
- Not recommended for pregnant or breastfeeding women
- Consult healthcare provider before use, especially with existing conditions
- No human clinical trials published - all dosing extrapolated from animal studies
Regulatory status
- Not approved by the FDA for any indication.
- Supplied and described for laboratory research use only — not for human or veterinary use.
Community data
Community Insights
Based on data the community reported. Not clinical proof.
References
40% grip strength improvement in sedentary mice, 60% with exercise. No adverse effects observed.
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Supports oral administration viability.
Diet-induced obese mice showed 5.1% weight reduction, 30% adipocyte size reduction. Human equivalent ~5mg/kg/day using FDA allometric scaling.